OsteoProbe® RUO是在體測量骨組織材料性質(zhì)的**儀器，是實驗室和臨床研究中測量骨質(zhì)量的有力工具。OsteoProbe® RUO是一種便攜式單手操作微壓痕儀，與測量骨密度的放射性方法（X射線、DXA和CT）具有不同的原理，它使用參考點壓痕技術(shù)來檢測材料對局部壓力的抵抗性。
應用范圍：
OsteoProbe® RUO可測量骨組織的材料性質(zhì)，有助于加深對骨量的認識。骨由礦物質(zhì)和有機物（骨膠）組成，現(xiàn)有的技術(shù)只有提供有關(guān)礦物質(zhì)的信息，關(guān)于有機物的信息很少。由于缺少在體測量方法，臨床研究中難以得到骨的材料性質(zhì)，參考點壓痕技術(shù)則解決了這一難題，使得研究人員可以測量和監(jiān)測骨量的改變。
OsteoProbe® RUO measures and quantifies material properties of bone, providing a clearer understanding of Bone Quality. Bone is composed of mineral and organic (Bone Glue) building blocks. Current techniques provide detailed information about the mineral aspect but we suffer from limited information about the organic. Learn more about Bone Quality.
In the clinical setting, material properties of Bone Quality have been ignored due to the lack of a method for in vivo measurement. Reference Point Indentation (RPI) is a technique bringing change to the current situation in a clinical research setting. RPI enables researchers to have an in vivo method for directly measuring material aspects of bone quality. With RPI, researchers can measure and monitor longitudinal changes in the material quality of bone.
相關(guān)文獻：
[1] F. Malgo, N.A. Hamdy, S.E. Papapoulos, N.M. Appelman-Dijkstra. Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density. J. Clin. Endocrinol. Metab., 100 (2012), pp. 2039-2045
[2] J.N. Farr, M.T. Drake, S. Amin, L.J.M. Iii, L.K. Mccready. In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes. J. Bone Miner. Res. 29 (2014), pp. 787-795
OsteoProbe® RUO Publications
· Are the High Hip Fracture Rates Among Norwegian Women Explained by Impaired Bone Material Properties
Journal of Bone and Mineral Research, Dr. Erik Eriksen et al, 2015
· Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density
Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015
· Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez et al, 2015
· Study of indentation of a sample equine bone using finite element simulation and single cycle reference point indentation
Journal of the Mechanical Behavior of Biomedical Materials, Dr. Henry Yang et al, 2015
· In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes
Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013
· Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength
Journal of Medical Devices, Dr. Paul Hansma, 2013
· A new device for performing reference point indentation without a reference probe
Review of Scientific Instruments, Dr. Paul Hansma, 2012